The application characteristics of analytical chemistry products, citric triethyl ester preparations

Citric triethyl ester analytical chemistry products, as a polyol ester compound, exhibit application characteristics such as plasticization, solubilization, and stabilization. Through its synergistic effect with drugs or excipients, it improves the performance of the preparations. These characteristics of citric triethyl ester make it a commonly used excipient in the pharmaceutical industry.
The plasticizing property is the core application of citric triethyl ester in preparations. It can reduce the glass transition temperature (Tg) of polymers (such as hydroxypropyl methylcellulose and cellulose acetate) by 10-20℃, enhancing the flexibility of the coating film and increasing the elongation at break by 50%-100%, preventing cracking and peeling during tablet coating. The plasticizing efficiency of analytical chemistry products, citric triethyl ester, increases with the increase in dosage (usually 10%-30% of the polymer weight), but excessive dosage will cause the film material to become sticky, affecting the appearance of the preparation.
The solubilization effect expands the application scenarios of analytical chemistry products, citric triethyl ester. It can dissolve lipid-soluble drugs (such as vitamin E and progesterone) at a concentration of 50-100mg/mL. By forming intermolecular hydrogen bonds, it increases the dispersion of the drug in aqueous media, enhancing the drug dissolution rate by 20%-30%. The solubilization effect of citric triethyl ester is stable within the pH range of 3-7 and is compatible with common surfactants, allowing for recombination to enhance the solubilization ability.
Stability regulation is an important application characteristic of analytical chemistry products, citric triethyl ester. It has a certain antioxidant capacity (DPPH free radical scavenging rate of 15%-20%), which can inhibit the oxidative degradation of drugs. When added at 0.5%-1% in lipid-containing preparations, it can extend the oxidation induction period by 2-3 times. Citric triethyl ester has high chemical stability and does not decompose significantly under 121℃ sterilization conditions. Its chelation ability with metal ions is weak (stable constant <10), and it does not affect the active ingredients in the preparation.
Safety and compatibility support the wide application of analytical chemistry products, citric triethyl ester. Its oral hazard is low (LD50 of rats > 5000mg/kg), and there are no strict restrictions on the residue in the preparation. It has good compatibility with natural excipients such as gelatin and starch, and does not cause cross-linking or precipitation. The application characteristics of citric triethyl ester preparations enable it to play an important role in various dosage forms such as film coating, soft capsules, and sustained-release preparations.
The application characteristics of analytical chemistry products, citric triethyl ester preparations, stem from the synergistic effect of the ester group and hydroxyl group in their molecular structure. These characteristics enable it to meet the performance requirements of different preparations and become an important choice in pharmaceutical excipients.